Research in sleep-disordered breathing (SDB)
Through ResMed’s strong partnerships within the global medical community, we are committed to supporting and engaging in SDB research that:
- leverages real-world evidence (RWE) to gain new perspectives on SDB patients’ responses and outcomes
- investigates the benefits of digital health technologies to support therapy adherence
- evaluates the efficacy of OSA therapies
Real-world evidence studies focusing on PAP therapy for OSA patients
ALASKA study outcomes: first publication1
The first outcomes from the ALASKA study showed that it’s important to consider patient phenotyping and personalised care when developing integrated sleep apnoea management strategies.
ALASKA study results: second and third publication2,3
Outcomes from the ALASKA study found that not only does the chance of survival increase by 39% if PAP therapy is continued for the first year, there are also survival benefits for patients who resume CPAP after an initial discontinuation.
PATHOS: Prevalence and predictors of PAP usage in OSA4
This German retrospective study of 22,317 obstructive sleep apnoea patients found only 55% of all eligible patients were prescribed PAP therapy. It highlighted the significant predictors of PAP treatment.
Support for investigator initiated research
ResMed believes in the need to support ethical, independent clinical research, conducted by qualified third-party investigators.
* Please note the Narval CC mandibular advancement device is not available in England, Scotland or Wales.
Narval CC is indicated to treat adults with snoring or mild to moderate obstructive sleep apnoea (OSA). In cases of severe OSA, it is indicated after continuous positive airway pressure (CPAP) therapy failure, non-compliance or refusal.
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References:
- Pépin, J.-L.; Bailly, S.; Rinder, P.; Adler, D.; Szeftel, D.; Malhotra, A.; Cistulli, P.A.; Benjafield, A.; Lavergne, F.; Josseran, ; et al. CPAP Therapy Termination Rates by OSA Phenotype: A French Nationwide Database Analysis. J. Clin. Med. 2021, 10, 936. https://doi.org/10.3390/jcm10050936
Retrospective analysis on 480 000 adult patients with CPAP therapy initiated from 2015 to end of 2016, identified in the French Health insurance claims database, and followed up until end of 2019 - Pépin JL et al. Relationship Between CPAP Termination and All-Cause Mortality: A French Nationwide Database Analysis. Chest. 2022 Jun;161(6):1657-1665. doi: 10.1016/j.chest.2022.02.013.
- Pépin JL et al. CPAP resumption after a first termination and impact on all-cause mortality in France. Eur Respir J. 2024 Feb 1;63(2):2301171. doi: 10.1183/13993003.01171-2023.
- Woehrle, H., Arzt, M., Ficker, J.H. et al. Prevalence and predictors of positive airway pressure therapy prescription in obstructive sleep apnoea: a population-representative study. Somnologie (2023). https://doi.org/10.1007/s11818-023-00435-2
Last update: 06/2024